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However, by using different FLNA dominant negative mutants that selectively abolished the ability of FLNA to interact with SST2 (FLNA repeats 1920) or to function as scaffold for partner proteins (FLNA 2124), the authors demonstrated that FLNA plays both a structural role, by stabilizing SST2 expression after prolonged stimulation with a specific agonist, and a functional role, acting as scaffold protein for molecules involved in signal transduction

In this study, we employed targeted metabolomic profiling in two distinct murine models of lung inflammation: one induced by LPS, a bacterial endotoxin that simulates infectious pneumonia, and the other induced by papain, a cysteine protease that models allergic and non-infectious airway injury ( in vivo and in vitro

PMID: 29181666